Commercial real estate regeneration markets are analysed in the context of the debate over the role of institutional investors in financing regeneration development as a primary source of the sustainable funding. This research aims to explore whether urban policy fosters economic sustainability of the regeneration real estate market by strengthening the scope of its maturity, resilience and competitiveness with the influence of municipal planning instruments and political leadership through regeneration policies. The research design of this research is embedded in the structure of the conceptual framework on market sustainability. Two sets of the property indices constructed constitute the rental values of the regeneration properties and standing properties in Manchester city centre respectively during the period from 1967 to 2017. This approach aims to evaluate the performance of the regeneration property market against the performance of the mainstream property market in Manchester as well as to assess the quantitative movements of the market performance indicating the level of economic sustainability. The evidence of rental value movement between 1984 and 2017 shows that the regeneration market has become more mature particularly after 1998 with steadily stable trends. Within the timeframe of the three property cycles, it can be observed that the rental value of regeneration properties after 1997 became more closely aligned with that of non-regeneration properties indicating a sign of market maturity. The evidence indicates that the regeneration office market is less economically resilient due to the higher possibility of being exposed to greater investment risk. The regeneration office market in Manchester city centre demonstrates a positive stature in achieving economic sustainability enhanced by Manchester being an economically resilient city able to compete for investment.