There are many institutionalized forms and initiatives supporting technology transfer between university and industry. They include science parks, centres of technology transfer, centres of innovation and incubators. Although their primary role is to encourage technology transfer, they also provide for job creation and regional economic development. Most countries implement a policy supporting the commercialization of research. The paper presents a picture of innovation centre system in Poland and proposes a framework to identify and evaluate costs and benefits of innovation centre in the local context. The framework takes into consideration efficiency and effectiveness of the different forms of innovation centres and their direct and indirect local effects. The analysis shows that the impact of the innovation centre on the local economy depends on the type of the innovation centre and characteristics of the local economy, and short and long term external effects should be taken into account. Moreover, the research connects the idea of innovation and infrastructure innovation development with the concept of sustainable development.