Multi Center development of Istanbul shifted the CBD and new sub centers emerged along east and west coast of Marmara shoreline. The recent 3rd bridge construction and proposed 3rd international airport on the northern part of the city, commercial activities will shift according to this new higher level of planning agenda. This paper analysis the determinants of office rents with respect to district level of commercial activity, proximity to external amenities, accessibility to means of transportation, sub district level income, house prices and demographics.