This paper is focused on the location factors of corporate headquarters in the South African context, with a particular attention to companies listed in the Johannesburg Stock Exchange (JSE). The paper seeks to investigate the regional nodes that likely influences headquarters location decisions. In so doing, the study seeks to understand how the metropolitan specialisation likely influence corporate headquarters location. The framework adopted in this study is that headquarters agglomerate in particular metropolitan areas due to control power and network power. However, the nodes of the metropolitan areas power and network do change with the changes in the environment.